2-FUN was an integrated project running from February 2007 to January 2011, funded under the EU sixth framework programme (FP6) a grant funding programme,focusing on health issues related to environmental conditions and pressures. Gathering 12 project partners coordinated by the Institut National de l’Environnement Industriel et des Risques in France, the project team used a multidisciplinary networking approach engaging a number of chemists, toxicologists, doctors, veterinaries, mathematicians and many more types of experts. Two related projects funded under the same framework programme are INTARESE and HEIMTSA. The first project focused on framework and guidance; the second on integrated assessment using epidemiological data. This project focused on indirect exposures and toxicological risk assessment from a conventional approach based on laboratory animal data. All three project developed methods and cutting-edge tools to help decision-makers define their priorities in environmental health management. These three projects have significantly advanced the research frontier within the field of integrated health risk assessment.