Field: Damage-reducing technique, Sustainable living
Global Technical function: Managing
Technical Function Unit: Networking, Software tool, Strategic planning
Geographic Area: France


2-FUN was an integrated project running from February 2007 to January 2011, funded under the EU sixth framework programme (FP6) a grant funding programme,focusing on health issues related to environmental conditions and pressures. Gathering 12 project partners coordinated by the Institut National de l’Environnement Industriel et des Risques in France, the project team used a multidisciplinary networking approach engaging a number of chemists, toxicologists, doctors, veterinaries, mathematicians and many more types of experts. Two related projects funded under the same framework programme are INTARESE and HEIMTSA. The first project focused on framework and guidance; the second on integrated assessment using epidemiological data. This project focused on indirect exposures and toxicological risk assessment from a conventional approach based on laboratory animal data. All three project developed methods and cutting-edge tools to help decision-makers define their priorities in environmental health management. These three projects have significantly advanced the research frontier within the field of integrated health risk assessment.

This project has significantly contributed to the family of strategic planning tools and
damage-reducing techniques for managing integrated environmental health risks, supporting decision makers’ analysis of current and future developments in the field of sustainable living achievement. Through future scenarios based on socio-economic, environmental and health components, the project team created a full-chain approach for health risk assessment which also integrated child related issues and uncertainty models. The main results from the project are the development of the following models:

  • Multimedia modelling software
  • PBPK modelling tool

These models have both been integrated into a commercial software tool, but can also be used individually.  They are ready for dissemination and use but might need additional standardization. Thus, the technology readiness level reaches a level 8 on the TRL scale.

Besides from the models mentioned above, there also other models and methods developed within the project, such as mathgnostics models, QSAR models and a risk-based tool for the regional ranking of environmental chemical stressors. Several methodologies, for instance the
methodologies for downscaling local climate and socio-economic scenarios are used for defining exposure scenarios, performing uncertainty analysis and dose-response analyses together with the other models and tools. The project is thereby supporting the evaluation and ranking of management options through a range of functionalities able to generate outputs of high concern for health risk assessment: building of long-term environmental and socio-economic scenarios, exposure and effects assessment, provision of uncertainty margins, and identification of sensitive pathways and risks. The models and tools developed within project have been tested on three contrasted case studies covering a range of temporal, spatial, sectorial, environmental and societal contexts requiring comprehensive health risk assessments, including:

  • Case study no.1: Air pollution and climate change in Portugal
  • Case study no.2: Choices of industrial technologies to minimise the impact on a river watershed in France
  • Case study no.3: Health risk assessment for children living in Upper Silesia, Poland.